The Design of a Distributed Database for Doctoral Studies Management

This paper aims to create a system that manages doctoral school requirements. The management of doctoral school implies administration of information like PhD personal information, Supervisors, Teachers, and other information that may be useful. We will debate on distributed database term as the proposed database project will have the same structure for four universities. Each university will be able to work on this database by accessing its own set of data and properly using the information received. This project will track the creation of a database to manage all the information needed and provide answers using these data.Distributed Database, Fragmentation, Top-Down Design Process

SOFTWARE DEVELOPMENT BUSINESS MOVING TOWARDS A UNIFIED COLLABORATIVE SYSTEM IN IT. SAAS MAY BE THE NEW ORIENTATION.

In this paper we will present an alternative way of programming. Our opinion is that, in the next few years, software development business will suffer serious changes. Software vendors will adopt SaaS (Software as a Service) as the new way of selling their products. We will try to guide you through the basic concepts of this relatively new domain. The article also includes a brief description of an application, developed indoor but using SaaS applications for some of its modules. In the end we want to make an SWOT analysis of the opportunity of using SaaS.Software as a service (SaaS), informatics, business, vendors, new technology.

A COLLABORATIVE MODEL FOR VIRTUAL ENTERPRISE

Collaborative process characteristics have three dimensions: actors, activities and action’s logic. The aim of this paper is to present a virtual portal’s model that helps managing consortiums. Our model based on dynamic e-collaboration and it has a modular structure, multilayer approach. System’s functionality of virtual enterprise is collaborative model is concern on users’ login, based on role and access control, searching and providing distributed resources, accessibility, metadata management and improved information’s management. Our proposal for developing solution offers a functional architecture of a virtual enterprise using dynamic e-collaboration and shared space.dynamic e-collaboration, multilayer solution, modular approach

A HIERACHICAL MODEL FOR MEDICAL REGISTRATIONS

The aim of this paper is to improve solutions for developing and improving medical and pharmaceutical services. We made a SWOT analyze of SIUI in order to build a document management system and create medical registration papers, based on collaborative editing and international medical standard. This model was focused on hierarchical decomposition of PHR and EHR records, using modular solution, which stores all data in XML files. It requires a system that is simple to use and allows users to focus their efforts on the content rather that on the technology used to create it. This approach allows a great flexibility in handling document and user interaction.medical registrations, HME standards, PHR, SIUI, hierarchical decomposition

Temporal Modulation of Drug Desensitization Procedures

Drug hypersensitivity reactions are an unavoidable clinical consequence of the presence of new therapeutic agents. These adverse reactions concern patients afflicted with infectious diseases (e.g., hypersensitivity to antibiotics), and with non-infectious chronic diseases, such as in cancers, diabetes or cystic fibrosis treatments, and may occur at the first drug administration or after repeated exposures. Here we revise recent key studies on the mechanisms underlying the desensitization protocols, and propose an additional temporal regulation layer that is based on the circadian control of the signaling pathway involved and on the modulation of the memory effects established by the desensitization procedures

Erroneous detection of desensitization doses in the prevention of hypersensitivity reactions

Abstract Background Desensitization protocols have empirically established their efficacy and safety in eliminating most of the hypersensitivity reactions to drugs and other allergens. Without such procedures, the offending drugs can otherwise be lethal, for some patients, when singularly administered at therapeutic doses. These binding events and the subsequent signaling cascades have been extensively modulated by different desensitization methods, without any clear explanation as to why it is necessary to use increasing allergen doses. Purpose To use a novel theoretical approach in order to model the desensitization algorithms currently in practice, that seeks to shed light on the mechanism behind their clinical efficacy. Method An approach using signal processing concepts is applied in this work to introduce aliasing as the erroneous detection of higher drug doses responsible for the efficacy of desensitization procedures. Results Available experimental data is modeled and correct predictions as to the efficacy of the drug treatment procedures are produced. Conclusions Desensitization algorithms may benefit from using concepts from signal processing theory in order to avoid hypersensitivity reactions

SOFTWARE DEVELOPMENT BUSINESS MOVING TOWARDS A UNIFIED COLLABORATIVE SYSTEM IN IT. SAAS MAY BE THE NEW ORIENTATION.

In this paper we will present an alternative way of programming. Our opinion is that, in the next few years, software development business will suffer serious changes. Software vendors will adopt SaaS (Software as a Service) as the new way of selling their products. We will try to guide you through the basic concepts of this relatively new domain. The article also includes a brief description of an application, developed indoor but using SaaS applications for some of its modules. In the end we want to make an SWOT analysis of the opportunity of using SaaS

Joint Use of SCOR and VRM

Supply Chain Operations Reference (SCOR) and Value Reference Model (VRM) are two popular business process reference models. Practitioners have suggested integrating these frameworks for achieving maximum value from the reference models. However, there are no methods and tools available for the integration of SCOR and VRM. The goal of the research is to find similarities and patterns of differences in the aforementioned reference models. The obtained results are applied to propose blueprint of guidelines for joint use of SCOR and VRM. The paper also presents a comparison between SCOR and VRM from several perspectives, which can support a semantic realignment of processes between the categories proposed by the two management frameworks

Variation of Anti-inflammatory Cytokines in Relationship with Menopause

Aim. The aim of this study was to assess serum levels of the key anti-inflammatory cytokines in women of reproductive age and in pre and postmenopausal women. Material and Method. 175 women were enrolled and were divided into 5 groups (1 – Fertile women; 2 – Pre- and perimenopausal women; 3 – Postmenopausal women; 4 – Surgically-induced menopause; 5 – Chronic inflammation). Multiplex cytokine kits were used to evaluate serum levels of interleukin-4, -10 and -13. We determined the serum levels of follicle stimulating hormone, of luteinizing hormone, 17β-estradiol, progesterone, dehydroepiandrosterone and dehydroepiandrosterone sulfate using sandwich ELISA. Results. IL-4, IL-10 and IL-17 present a statistically significant decrease (p=0.00, p=0.00, respectively p=0.0053) in women with natural or surgically induced menopause (groups 3 and 4), compared with fertile women and premenopausal women (Groups 1, 2 and 5). Serum levels of IL-4 and IL-10 are significantly higher in fertile patients with associated chronic inflammatory diseases (133.5±1.314 pg/ml, respectively 6.406±13.47 pg/ml) than in fertile patients without chronic inflammatory diseases or premenopausal women (84.67±1.22 pg/ml, respectively 0.627±0.714). Conclusions. IL-4 and IL-10, together with IL-17, show significantly lower serum values in patients with natural or surgically induced menopause compared with patients of childbearing age or in premenopause. IL-4 and IL-10 show significantly higher serum values for patients of childbearing age presenting chronic inflammatory pathology compared with patients of childbearing age without chronic inflammatory pathology or premenopausal patients

PICA ischemic stroke: The importance of urgent neurosurgical treatment

The posterior inferior cerebellar artery (PICA) has a unique anatomical complexity, which is of great clinical importance and is involved in many pathologies, such as aneurysm, ischemic stroke, neurovascular compression syndrome (NVCS), arteriovenous malformation (AVM) and brain tumour (1). PICA has a sinuous and variable trajectory, divided into 5 segments. PICA infarction usually manifests lateral bulbar syndrome and is more likely to cause mass effects. PICA frequently compresses the bulb and cranial nerves, resulting in various neurovascular compression syndromes (NVCS) (2). The ischemic stroke caused by thromboembolism in the PICA segment is accounted for more than 2% of all cases of ischemic stroke (3). Moreover, it tends to be underdiagnosed due to the symptomatology, represented usually by vertigo which mimics a possible peripheral vestibulopathy (4).  &nbsp